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K~@K~@Forms,,,,,,,,,,* K~@K~@DataAccessPages@@@@@@@@@@> @@MSysRelationshipsDDDDDDDDDDB @@MSysQueries88888888886 @@MSysACEs22222222220 @@MSysObjects88888888886 @w_X@MSysDb@r:::......., @@@Relationships<<<<<<<<<<: @@Databases44444444442 @@Tables.........., YNY  Y AllocRuleIdFunctionYAllocRuleIdv1p["ED50"]*(90-p["E0"])/(p["Emax"]-90+p["E0"])5_Y\\\NY Y  Y  Y \AllocRuleIdMinOrMaxOperatorCritYYAllocRuleIdv1  OY\\\NY  Y  Y  Y \dAllocRuleIdULRandomRuleiYAllocRuleIdv1  3YNY Y Y Y QuantileIdAllocRuleIdQW   苀   苉   苀YYYAllocRuleIdPrimaryKeyQuantileIdv1    YNY  Y  Y dY AllocRuleId NotesAllocRuleTypeSelected88"888#8YYAllocRuleIdPrimaryKeyHv1bT@!COPTD-optimal designDOPT*$LVALC-optimal for ED90: dose producing RO= 90%     hY N%%  Y Y  Y dY Y CohortDoseIdCohortId DoseXSamples Fixed  %'   %(   %) YYYCohortDoseIdCohortIdPrimaryKeyv1@@$ |eN6 100 75 50 30 20 10 5 2 0  $ @&&&&&&&& & $ @&&&&&&&&& $ @&&&&&&&& & .YN  ++Y Y  Y Y  Y 8d Y 8d Y d Y d Y 8dY  Y  CohortIdCohortNbCohortNotesCohortSizeRandomRuleCreatedUserCreatedDateResultsUserResultsDateHasResultsSelected88+-888+.8YYCohortIdPrimaryKey++Hv1b@ *  Next cohortbestadmin11/14/2007 3:32 PMFFF2+% *,*, hYN00Y Y  Y d Y  Y  d Y dY DataSetIdDataSetNbDataSetNameDataSetDescCreatedUserCreatedDate Locked  01   02 YYDataSetIdPrimaryKeyv1 / / +YN44Y  Y d Y dY  DoseId DoseX DoseYDataSetId  45 苀  46 苀  47 苉YYYDataSetId DoseIdPrimaryKeyv1@  3 3 3a YN99Y Y  Y d Y  Y  d Y dY Y DataSetIdDataSetNbDataSetNameDataSetDescCreatedUserCreatedDate LockedDataForAna   9;    9< YYDataSetIdPrimaryKeyv1j8zCohort 1Burin-in cohort includes 6 subjects across 3 dose levels; 0, 10 and 70mgadmin11/14/2007 3:25 PMye^ 8:8: Y=N>>Y  Y dY Y  Y Y  DoseId DoseX DoseYDataSetIdDataForAnaDataSummaryId  >@ 苀  >A 苀  >B 苀  >C 苉YYYYDataSetIdDataSummaryId DoseIdPrimaryKeyHv1b$=_>GzW@75/(\…Z@75/GzE@10/ Gz8@10/ )\(0/ (\(0/ = @?????? = @?????? = @ ? ? ???? = @ ? ? ????rYNEE Y dSimDataTypedv@@DnormalmY NHH Y tY  DoseX DoseYdv Y $NJJ  Y  Y dY Y  Y Y Y Y  DoseId DoseXMeanStdSamplesDataForAnaAdditionalGroupDataSetId  JL 苀  JM 苀  JN 苉YYYDataSetId DoseIdPrimaryKeyv1@ tI b9 @X@ @100#@W@ @75"S@ @50"M@ @30"I@ @20"B@ @10"4@ @5 $@ @2  @0  I @KKKKKKKKK I @KKKKKKKK K I @KKKKKKKK K YN  PPY Y  Y d Y  Y 8d Y 8 Y d Y d Y 8d Y  8dDecisionRuleIdDecisionRuleNb DecisionRuleNameDerivParamCriteria NotesOperator1Treshold1Operator2treshold288PR888PS8YYDecisionRuleIdPrimaryKeyPPHv1bO SMAD ED90p["ED50"]*(90-p["E0"])/(p["Emax"]-90+p["E0"])mad(der)/median(der)<=.1>=0fd`\XXB Mean ED90p["ED50"]*(90-p["E0"])/(p["Emax"]-90+p["E0"]) mean(der) <=100>0\ZXSOOBOQQOQQ#YNUU Y d Y d Y d Y d Y  dY NumberOfChainsSeedSizeOfBurninThin SizeOfSimulationRandomSeed  UW 苀YNumberOfChainsv1@@T1110500011000 T8V3YNYY Y d Y FieldNameFieldTextY]Y0Index_2CF36DFC_038B_4136YYv1 X~?SimRes_WinbugsFiles @\4(Results_WinbugsFiles6@[6*Results_Model_simul1000:(Results_Model_chain16(LVAL# model: model { for (i in 1:n.obs) {y[i]~dnorm(mean[i],tau) mean[i]<-E0 + Emax * pow(x[i], gamma)/(pow(ED50, gamma) + pow(x[i], gamma))} E0~dnorm(0,.001) Emax~dnorm(100,.001) ED50~dnorm(5,.001) gamma<-1 tau~dgamma(.001,.001) # Loop over prediction range for (i in 1:n.pred) {mean.pred[i]<-E0 + Emax * pow(x.pred[i], gamma)/(pow(ED50, gamma) + pow(x.pred[i], gamma)) ind.pred[i]~dnorm(mean.pred[i],tau)}} # prior inits for chain 1: list(E0=0.00000E+00, Emax=1.00000E+02, ED50=1.00000E+00, tau=1.00000E+00) # data: list(x.pred=c(0.00000E+00, 2.00000E+00, 5.00000E+00, 1.00000E+01, 2.00000E+01, 3.00000E+01, 5.00000E+01, 7.50000E+01, 1.00000E+02), n.pred=9.00000E+00, n.obs=6.00000E+00, x=c(0.00000E+00, 0.00000E+00, 1.00000E+01, 1.00000E+01, 7.50000E+01, 7.50000E+01), y=c(-1.23800E+01, -6.30000E-01, 2.49300E+01, 4.38600E+01, 1.06090E+02, 9.40700E+01)) JLVALZ# model: model { for (i in 1:n.obs) {y[i]~dnorm(mean[i],tau) mean[i]<-E0 + Emax * pow(x[i], gamma)/(pow(ED50, gamma) + pow(x[i], gamma))} E0~dnorm(0,.001) Emax~dnorm(100,.001) ED50~dnorm(5,.001) gamma<-1 tau~dgamma(.001,.001) # Loop over prediction range for (i in 1:n.pred) {mean.pred[i]<-E0 + Emax * pow(x.pred[i], gamma)/(pow(ED50, gamma) + pow(x.pred[i], gamma)) ind.pred[i]~dnorm(mean.pred[i],tau)}} # prior inits for chain 1: list(E0=0.00000E+00, Emax=1.00000E+02, ED50=1.00000E+00, tau=1.00000E+00) # data: list(x.pred=c(0.00000E+00, 2.00000E+00, 5.00000E+00, 1.00000E+01, 2.00000E+01, 3.00000E+01, 5.00000E+01, 7.50000E+01, 1.00000E+02), n.pred=9.00000E+00, n.obs=1.80000E+01, x=c(0.00000E+00, 0.00000E+00, 1.00000E+01, 1.00000E+01, 7.50000E+01, 7.50000E+01, 2.00000E+00, 2.00000E+00, 1.00000E+02, 1.00000E+02, 1.00000E+02, 1.00000E+02, 1.00000E+02, 1.00000E+02, 1.00000E+02, 1.00000E+02, 5.00000E+01, 5.00000E+01), y=c(-1.99415E+01, 2.65764E+00, 5.59374E+01, 4.90136E+01, 1.12264E+02, 8.91728E+01, 1.55161E+01, -9.21210E-01, 9.02505E+01, 9.07923E+01, 9.25421E+01, 9.19754E+01, 1.07097E+02, 9.46070E+01, 1.10915E+02, 9.76441E+01, 7.98943E+01, 6.93781E+01))  XiQko^mk+`dOQ^+MWJYbZiQko^mk+`dOQ^+kY`o^ZiQko^mk+sYbLoUkSY^QkZkY`iQk+sYbLoUkSY^QkZwY\\\N__ Y dY Y Y ModuleName IncludedOnImportLockedOnImportValidated_aSeYPrimaryKeyv1L^fSimulation plan Simulation data Estimation model Decision rules Analyse dataAllocation rules  ^@J^^dMJmYdbio^Qk`JbJ^vkQOJmJ`OQMYkYdbio^Qk`QkmY`JmYdb`dOQ^`kY`o^JmYdbOJmJ`kY`o^JmYdbf^Jb` YNccY Y DataIDlechYAOIndexv1Kb[ dM0(3DPwSysAccessObjects?LLLLLLLLLLJ Kb[ࡱ>   Root Entry ,Nc@ VBA`^$+,NcVBAProject`w*+,NcVBA`w*+pldir_VBA_PROJECTPROJECT,5PROJECTwm1  !"#$%&'()*+-./0鱀0* pHd Access9dDb0@ = p N? 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